Endocrine Abstracts

Behavior of thyroid function tests in a Brazilian elderly population using Big DataIntroduction: Interpretation of thyroid function data has changed over the last decades with several groups demonstrating changing in the thyroid axis with aging, particularly with a progressive increase in age-related TSH. With the proliferation of studies with large datasets, termed Big Data, sample sizes are no longer a challenge, and the possibility of using clinical l...

Correlation of three thyroglobulin assays in the management of differentiated thyroid cancer (DTC) patientsIntroduction: Thyroglobulin(Tg) is the main biochemical marker of DTC. Usual immunometric assays(IMA) are prone to interference by autoantibodies which can lead to erroneous results. LC-MS/MS has been described as an assay that may provide accurate results, however the literature reported up to 40% of undetectable rates in patients with positive thy...

Hypophosphatasia (HPP) is an inherited skeletal disease characterized by defective bone mineralization due to a deficiency in tissue-nonspecific alkaline phosphatase (TNALP). Patients with the severe infantile form of HPP have a poor prognosis that often results in high mortality by one year. Asfotase alfa is an approved therapy for HPP, while requires chronic injections to maintain efficacy. To develop a one-time gene therapy for HPP, we examined the safety and efficacy of AA...

Introduction: Angiosarcomas account for < 1% of all sarcomas, and are highly agressive neoplasms whose clinical course is striking: local recurrence, metastasis, and a high mortality rate. Primary angiosarcoma of the adrenal gland was first described in 1988 by Kareti et al. and is very rare with, so far, only 51 reported cases. Case report: A 49-year-old male, without prior malignancy, presented with a 4.9x5.9 cm right adrenal nodule and a 2.4 cm le...

Introduction: The bidirectional relationship of risk between breast cancer (BC) and thyroid cancer (TC) has been debated. Estrogens are proposed as agents implicated in the risk of developing TC promoting thyroid tumorigenesis. Therapies that reduce the effect of estrogens on their receptors in cancer cells are widely used.Objective: To correlate the use of hormonal therapy in BC with the prevalence of TC.Material and Methods: We p...

Introduction: The endocrine complications of COVID-19 remain largely unknown. Cases of central diabetes insipidus (CDI) have been reported after COVID-19, with hypophysitis being the most likely cause. COVID-19 vaccines potential adverse effects may mimetize some of these complications. We present a case of a woman who developed CDI one week after the 2 nd dose of BNT162b2 mRNA COVID-19 vaccine.Case Report: Female patient, 37 years old, with rheumatoid a...

Introduction: 17 alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease caused by mutations in the CYP17A gene, representing 1% of cases of Congenital Adrenal Hyperplasia (CAH). The accumulation of mineralocorticoids and the glucocorticoid effect of corticosterone induce high blood pressure (HBP) and hypokalemia.Clinical Case: A 44 year-old female reporting HBP since the age of 20 years and without chronic medication, presented at the...

Background: Graves’ Disease (GD) is one of the most common organ specific autoimmune disorders, being characterized by an abnormal production of stimulating autoantibodies to the thyrotropin receptor (TSHR). Some studies demonstrated that genetic polymorphisms in certain cytokines, namely interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), are associated with a greater susceptibility of developing GD. Our aim was to evaluate ...

Introduction: Graves orbitopathy is the major extrathyroidal manifestation of Graves Disease (GD). The approach depends on its clinical activity and severity. Treatment and referral to specialized centers, with Endocrinology and Ophthalmology, has a strong impact on the prognosis of Graves’ Disease (GD) and GO.Cases report: We report four cases of DG with OG. Their characteristics and clinical evolution are shown in Table 1.<table boarder="1" ce...

Purpose: To assess the impact of serum corrected calcium (CorrCa), magnesium (Mg) and phosphorus (P) levels at hospital admission on SARS-CoV-2 infection outcome.Methods: In this retrospective study, all adult patients with laboratory-confirmed COVID-19 hospitalized in Hospital Universitario Puerta de Hierro Madadahonda during 2020 were included. Demographic, clinical and laboratory data were registered and related to the prognosis of the disease. Poor o...